GETTING MY NR1-SITE TO WORK

Working with this method, Kalbaugh et al. assigned affinity and efficacy roles to positions inside the LBDs with the NR1 and NR2A NMDAR subunits. In situ mutation of residues in immediate contact with bound ligand afflicted both efficacy and affinity, although positions that stabilize the closed cleft conformation with out a direct ligand interacti